None of them make the game drastically different, but they do make enough changes that, in some cases, it'll feel like playing a new campaign, I'd say. If you're craving a different experience, though, there are balancing mods and also a few overhaul ones. That said, as a returning player myself (I played the IZJS version much more recently than 2007, though it's been a few years), I don't think any mods are strictly necessary.
Note that XII's modding support is rather limited (you won't be seeing anything as radical as Skyrim mods, for example). Originally posted by unnecesaurus (ꈍ ꒳ ꈍ✿):If you haven't played since 2007, it'll feel brand new without mods.